(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
(-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone...
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| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
2014
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| الوصول للمادة أونلاين: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627 http://cmuir.cmu.ac.th/handle/6653943832/7239 |
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| المؤسسة: | Chiang Mai University |
| اللغة: | English |
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th-cmuir.6653943832-72392014-08-30T03:51:43Z (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii Kampong R. Pompimon W. Meepowpan P. Sukdee S. Sombutsiri P. Nantasaen N. Krachodnok S. (-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50 values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50 values of 3.31, 3.26 and 1.89 μg/mL. 2014-08-30T03:51:43Z 2014-08-30T03:51:43Z 2013 Article 0972768X http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627 http://cmuir.cmu.ac.th/handle/6653943832/7239 English |
| institution |
Chiang Mai University |
| building |
Chiang Mai University Library |
| country |
Thailand |
| collection |
CMU Intellectual Repository |
| language |
English |
| description |
(-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50 values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50 values of 3.31, 3.26 and 1.89 μg/mL. |
| format |
Article |
| author |
Kampong R. Pompimon W. Meepowpan P. Sukdee S. Sombutsiri P. Nantasaen N. Krachodnok S. |
| spellingShingle |
Kampong R. Pompimon W. Meepowpan P. Sukdee S. Sombutsiri P. Nantasaen N. Krachodnok S. (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| author_facet |
Kampong R. Pompimon W. Meepowpan P. Sukdee S. Sombutsiri P. Nantasaen N. Krachodnok S. |
| author_sort |
Kampong R. |
| title |
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| title_short |
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| title_full |
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| title_fullStr |
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| title_full_unstemmed |
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii |
| title_sort |
(-)-7-o-acetylgoniodiol as cancer chemopreventive agent from goniothalamus griffithii |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627 http://cmuir.cmu.ac.th/handle/6653943832/7239 |
| _version_ |
1681420763227226112 |