(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii

(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii

(-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone...

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Main Authors: Kampong R., Pompimon W., Meepowpan P., Sukdee S., Sombutsiri P., Nantasaen N., Krachodnok S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627
http://cmuir.cmu.ac.th/handle/6653943832/7239
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-72392014-08-30T03:51:43Z (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii Kampong R. Pompimon W. Meepowpan P. Sukdee S. Sombutsiri P. Nantasaen N. Krachodnok S. (-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50 values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50 values of 3.31, 3.26 and 1.89 μg/mL. 2014-08-30T03:51:43Z 2014-08-30T03:51:43Z 2013 Article 0972768X http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627 http://cmuir.cmu.ac.th/handle/6653943832/7239 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description (-)-7-O-Acetylgoniodiol (1B) together with goniothalamin (2) and pinocembrin (3), have been isolated from leaves and twigs of Goniothalamus griffithii. All compounds were identified by spectroscopic analyses and comparison with published data. 1B can be formed by recrystallization from EtOH/acetone and its stereochemistry was further confirmed by X-ray crystallographic analysis. Goniothalamin exhibited most potent cytotoxicity against P-388, KB, Col-2, MCF-7, Lu-1, A549, T24, ASK, HEK-293 and cells with ED50 values of 0.19, 0.56, 0.36, 0.56, 0.54, 0.67, 0.39, 0.67 and 0.50 μg/mL, respectively. In addition, 1B was also showed high selective inhibitory effect on the P-388, KB and HEK-293 with ED50 values of 3.31, 3.26 and 1.89 μg/mL.
format Article
author Kampong R.
Pompimon W.
Meepowpan P.
Sukdee S.
Sombutsiri P.
Nantasaen N.
Krachodnok S.
spellingShingle Kampong R.
Pompimon W.
Meepowpan P.
Sukdee S.
Sombutsiri P.
Nantasaen N.
Krachodnok S.
(-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
author_facet Kampong R.
Pompimon W.
Meepowpan P.
Sukdee S.
Sombutsiri P.
Nantasaen N.
Krachodnok S.
author_sort Kampong R.
title (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_short (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_full (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_fullStr (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_full_unstemmed (-)-7-O-acetylgoniodiol as cancer chemopreventive agent from Goniothalamus Griffithii
title_sort (-)-7-o-acetylgoniodiol as cancer chemopreventive agent from goniothalamus griffithii
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557581&partnerID=40&md5=a74b594f9c446250f49f6127472e0627
http://cmuir.cmu.ac.th/handle/6653943832/7239
_version_ 1681420763227226112

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