Genotypes of hepatitis B virus among children in Chiang Mai, Thailand

In sub-Saharan Africa, the Pacific, and particularly Asia, hepatitis B virus (HBV) infection is highly endemic, the most common route of transmission is perinatal. To minimize the number of horizontal transmissions, we determined the prevalence of HBV genotypes among children in northern Thailand. F...

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Main Authors: Jutavijittum P., Yousukh A., Jiviriyawat Y., Kunachiwa W., Toriyama K.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-44949095497&partnerID=40&md5=0508e5056c124006d223e65263d93f7c
http://www.ncbi.nlm.nih.gov/pubmed/18564677
http://cmuir.cmu.ac.th/handle/6653943832/731
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-7312014-08-29T09:02:01Z Genotypes of hepatitis B virus among children in Chiang Mai, Thailand Jutavijittum P. Yousukh A. Jiviriyawat Y. Kunachiwa W. Toriyama K. In sub-Saharan Africa, the Pacific, and particularly Asia, hepatitis B virus (HBV) infection is highly endemic, the most common route of transmission is perinatal. To minimize the number of horizontal transmissions, we determined the prevalence of HBV genotypes among children in northern Thailand. From a survey of 1,231 schoolchildren in Chiang Mai during 1998 to 2000, 55 (4.5%) were found positive for HBsAg. Fifty-three HBsAg-positive samples were available for this study. These came from 28 girls (52.8%) and 25 boys (47.2%), age 5-16 years, with a mean age of 12.8 (±2.6) years. The laboratory method was based on a multiplex-PCR for the detection of 6 HBV genotypes (A-F). Among 53 HBsAg positive cases, 48 (90.6%) were genotype C, followed by 4 cases of genotype B (7.5%), and 1 case (1.9%) with mixed infection with genotypes B and C. The high prevalence of HBV genotype C follow by genotype B is similar to that found among blood donors in northern Thailand and the nationwide epidemiological survey conducted in 2004. Perinatal transmission may play an important role in the spread of the virus in this area, as in other Asian countries, where genotypes C and B are highly prevalent. 2014-08-29T09:02:01Z 2014-08-29T09:02:01Z 2008 Article 01251562 18564677 http://www.scopus.com/inward/record.url?eid=2-s2.0-44949095497&partnerID=40&md5=0508e5056c124006d223e65263d93f7c http://www.ncbi.nlm.nih.gov/pubmed/18564677 http://cmuir.cmu.ac.th/handle/6653943832/731 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description In sub-Saharan Africa, the Pacific, and particularly Asia, hepatitis B virus (HBV) infection is highly endemic, the most common route of transmission is perinatal. To minimize the number of horizontal transmissions, we determined the prevalence of HBV genotypes among children in northern Thailand. From a survey of 1,231 schoolchildren in Chiang Mai during 1998 to 2000, 55 (4.5%) were found positive for HBsAg. Fifty-three HBsAg-positive samples were available for this study. These came from 28 girls (52.8%) and 25 boys (47.2%), age 5-16 years, with a mean age of 12.8 (±2.6) years. The laboratory method was based on a multiplex-PCR for the detection of 6 HBV genotypes (A-F). Among 53 HBsAg positive cases, 48 (90.6%) were genotype C, followed by 4 cases of genotype B (7.5%), and 1 case (1.9%) with mixed infection with genotypes B and C. The high prevalence of HBV genotype C follow by genotype B is similar to that found among blood donors in northern Thailand and the nationwide epidemiological survey conducted in 2004. Perinatal transmission may play an important role in the spread of the virus in this area, as in other Asian countries, where genotypes C and B are highly prevalent.
format Article
author Jutavijittum P.
Yousukh A.
Jiviriyawat Y.
Kunachiwa W.
Toriyama K.
spellingShingle Jutavijittum P.
Yousukh A.
Jiviriyawat Y.
Kunachiwa W.
Toriyama K.
Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
author_facet Jutavijittum P.
Yousukh A.
Jiviriyawat Y.
Kunachiwa W.
Toriyama K.
author_sort Jutavijittum P.
title Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
title_short Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
title_full Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
title_fullStr Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
title_full_unstemmed Genotypes of hepatitis B virus among children in Chiang Mai, Thailand
title_sort genotypes of hepatitis b virus among children in chiang mai, thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-44949095497&partnerID=40&md5=0508e5056c124006d223e65263d93f7c
http://www.ncbi.nlm.nih.gov/pubmed/18564677
http://cmuir.cmu.ac.th/handle/6653943832/731
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