Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells

• Main Authors: Anuchapreeda S., Leechanachai P., Smith M.M., Ambudkar S.V., Limtrakul P.-N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037103569&partnerID=40&md5=b5b534bea267f4f3056d4548f797b52a; http://www.ncbi.nlm.nih.gov/pubmed/12167476; http://cmuir.cmu.ac.th/handle/6653943832/733
• Institution: Chiang Mai University

Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in the tumor cells of a patient, resulting from enhanced drug efflux. It is often related to the overexpression of P-glycoprotein (Pgp) on the surface of tumor cells, thereby reducing d...