Automatic Nevirapine concentration interpretation system using support vector regression

Follow-up of human immunodeficiency virus (HIV) patients treated with Nevirapine (NVP) is a necessary process to evaluate the drug resistance and the HIV mutation. It is also usually tested by immunochromatographic (IC) strip test. However, it is difficult to estimate the amount of drug the patient...

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Main Authors: Auephanwiriyakul S., Sumonphan E., Theera-Umpon N., Tayapiwatana C.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-79952040069&partnerID=40&md5=910ab0f28e94302d1ec5d71518832b4c
http://www.ncbi.nlm.nih.gov/pubmed/21257221
http://cmuir.cmu.ac.th/handle/6653943832/760
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-7602014-08-29T09:02:04Z Automatic Nevirapine concentration interpretation system using support vector regression Auephanwiriyakul S. Sumonphan E. Theera-Umpon N. Tayapiwatana C. Follow-up of human immunodeficiency virus (HIV) patients treated with Nevirapine (NVP) is a necessary process to evaluate the drug resistance and the HIV mutation. It is also usually tested by immunochromatographic (IC) strip test. However, it is difficult to estimate the amount of drug the patient gets by visually inspection of color. In this paper, we propose an automatic interpretation system using a commercialized optical scanner. Several IC strips can be placed at any direction as long as they are on the scanner plate. There are three steps in the system, i.e., light intensity normalization, image segmentation and NVP concentration interpretation. We utilized the Support Vector Regression to interpret the NVP concentration. From the results, we found out the performance of the system is promising and better than that of the linear and nonlinear regression. © 2011 Elsevier Ireland Ltd. 2014-08-29T09:02:04Z 2014-08-29T09:02:04Z 2011 Article 1692607 10.1016/j.cmpb.2010.12.014 21257221 CMPBE http://www.scopus.com/inward/record.url?eid=2-s2.0-79952040069&partnerID=40&md5=910ab0f28e94302d1ec5d71518832b4c http://www.ncbi.nlm.nih.gov/pubmed/21257221 http://cmuir.cmu.ac.th/handle/6653943832/760 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Follow-up of human immunodeficiency virus (HIV) patients treated with Nevirapine (NVP) is a necessary process to evaluate the drug resistance and the HIV mutation. It is also usually tested by immunochromatographic (IC) strip test. However, it is difficult to estimate the amount of drug the patient gets by visually inspection of color. In this paper, we propose an automatic interpretation system using a commercialized optical scanner. Several IC strips can be placed at any direction as long as they are on the scanner plate. There are three steps in the system, i.e., light intensity normalization, image segmentation and NVP concentration interpretation. We utilized the Support Vector Regression to interpret the NVP concentration. From the results, we found out the performance of the system is promising and better than that of the linear and nonlinear regression. © 2011 Elsevier Ireland Ltd.
format Article
author Auephanwiriyakul S.
Sumonphan E.
Theera-Umpon N.
Tayapiwatana C.
spellingShingle Auephanwiriyakul S.
Sumonphan E.
Theera-Umpon N.
Tayapiwatana C.
Automatic Nevirapine concentration interpretation system using support vector regression
author_facet Auephanwiriyakul S.
Sumonphan E.
Theera-Umpon N.
Tayapiwatana C.
author_sort Auephanwiriyakul S.
title Automatic Nevirapine concentration interpretation system using support vector regression
title_short Automatic Nevirapine concentration interpretation system using support vector regression
title_full Automatic Nevirapine concentration interpretation system using support vector regression
title_fullStr Automatic Nevirapine concentration interpretation system using support vector regression
title_full_unstemmed Automatic Nevirapine concentration interpretation system using support vector regression
title_sort automatic nevirapine concentration interpretation system using support vector regression
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-79952040069&partnerID=40&md5=910ab0f28e94302d1ec5d71518832b4c
http://www.ncbi.nlm.nih.gov/pubmed/21257221
http://cmuir.cmu.ac.th/handle/6653943832/760
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