Influence of body weight on achieving indinavir concentrations within its therapeutic window in HIV-infected thai patients receiving indinavir boosted with ritonavir

• Main Authors: Cressey T.R., Urien S., Hirt D., Halue G., Techapornroong M., Bowonwatanuwong C., Leenasirimakul P., Treluyer J.-M., Jourdain G., Lallemant M.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78751655782&partnerID=40&md5=49b4c4ab154d6f79944f341f14f49663; http://www.ncbi.nlm.nih.gov/pubmed/21233689; http://cmuir.cmu.ac.th/handle/6653943832/761
• Institution: Chiang Mai University

Indinavir boosted with ritonavir (IDV/r) dosing with 400/100 mg, twice daily, is preferred in Thai adults, but this dose can lead to concentrations close to the boundaries of its therapeutic window. The objectives of this analysis were to validate a population pharmacokinetic model to describe IDV/r...