Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach
Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methac...
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th-cmuir.6653943832-7642014-08-29T09:02:05Z Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach Kareuhanon W. Lee V.S. Nimmanpipug P. Tayapiwatana C. Pattarawarapan M. Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methacrylic acid (MAA) monomer and the selected templates, while equilibrium binding studies were applied to evaluate the polymer binding efficiency. The data indicated that NAM is the best candidate to prepare MIPs for retaining NVP due to a relatively similar binding energy between the NVP-MAA and NAM-MAA complex. The NAM-imprinted polymer showed a high binding affinity and selectivity toward NVP. When the polymer was applied as a sorbent in solid-phase extraction of NVP from human plasma, high recovery and reproducibility were obtained. © 2009 Vieweg+Teubner | GWV Fachverlage GmbH. 2014-08-29T09:02:05Z 2014-08-29T09:02:05Z 2009 Article 00095893 10.1365/s10337-009-1385-4 CHRGB http://www.scopus.com/inward/record.url?eid=2-s2.0-72349096643&partnerID=40&md5=3ecdf1601e2900f48efdc54fe5a9bcae http://cmuir.cmu.ac.th/handle/6653943832/764 English |
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Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methacrylic acid (MAA) monomer and the selected templates, while equilibrium binding studies were applied to evaluate the polymer binding efficiency. The data indicated that NAM is the best candidate to prepare MIPs for retaining NVP due to a relatively similar binding energy between the NVP-MAA and NAM-MAA complex. The NAM-imprinted polymer showed a high binding affinity and selectivity toward NVP. When the polymer was applied as a sorbent in solid-phase extraction of NVP from human plasma, high recovery and reproducibility were obtained. © 2009 Vieweg+Teubner | GWV Fachverlage GmbH. |
| format |
Article |
| author |
Kareuhanon W. Lee V.S. Nimmanpipug P. Tayapiwatana C. Pattarawarapan M. |
| spellingShingle |
Kareuhanon W. Lee V.S. Nimmanpipug P. Tayapiwatana C. Pattarawarapan M. Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| author_facet |
Kareuhanon W. Lee V.S. Nimmanpipug P. Tayapiwatana C. Pattarawarapan M. |
| author_sort |
Kareuhanon W. |
| title |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| title_short |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| title_full |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| title_fullStr |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| title_full_unstemmed |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| title_sort |
synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-72349096643&partnerID=40&md5=3ecdf1601e2900f48efdc54fe5a9bcae http://cmuir.cmu.ac.th/handle/6653943832/764 |
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