Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine
Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in th...
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2014
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th-cmuir.6653943832-7762014-08-29T09:02:06Z Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine Pornprasert S. Mary J.-Y. Faye A. Leechanachai P. Limtrakul A. Rugpao S. Sirivatanapa P. Gomuthbutra V. Matanasaravoot W. Le Coeur S. Lallemant M. Barre-Sinoussi F. Menu E. Ngo-Giang-Huong N. Ayouba A. Chailert S. Chaouat G. Derrien M. Dolcini G. Eteki N. Kfutwah A.J. Kouo O. Lemen B. Maldonado-Estrada J. Nerrienet E. Njinku B. Scarlatti G. Tejiokem M. Tene G. Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-10 mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (>72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1. © 2009 Bentham Science Publishers Ltd. 2014-08-29T09:02:06Z 2014-08-29T09:02:06Z 2009 Review 1570162X 10.2174/157016209787581472 19275589 CHRUB http://www.scopus.com/inward/record.url?eid=2-s2.0-64749097199&partnerID=40&md5=20c9efc3c607ff9233b90db77b0c4d47 http://www.ncbi.nlm.nih.gov/pubmed/19275589 http://cmuir.cmu.ac.th/handle/6653943832/776 English |
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Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-10 mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (>72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1. © 2009 Bentham Science Publishers Ltd. |
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Review |
author |
Pornprasert S. Mary J.-Y. Faye A. Leechanachai P. Limtrakul A. Rugpao S. Sirivatanapa P. Gomuthbutra V. Matanasaravoot W. Le Coeur S. Lallemant M. Barre-Sinoussi F. Menu E. Ngo-Giang-Huong N. Ayouba A. Chailert S. Chaouat G. Derrien M. Dolcini G. Eteki N. Kfutwah A.J. Kouo O. Lemen B. Maldonado-Estrada J. Nerrienet E. Njinku B. Scarlatti G. Tejiokem M. Tene G. |
spellingShingle |
Pornprasert S. Mary J.-Y. Faye A. Leechanachai P. Limtrakul A. Rugpao S. Sirivatanapa P. Gomuthbutra V. Matanasaravoot W. Le Coeur S. Lallemant M. Barre-Sinoussi F. Menu E. Ngo-Giang-Huong N. Ayouba A. Chailert S. Chaouat G. Derrien M. Dolcini G. Eteki N. Kfutwah A.J. Kouo O. Lemen B. Maldonado-Estrada J. Nerrienet E. Njinku B. Scarlatti G. Tejiokem M. Tene G. Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
author_facet |
Pornprasert S. Mary J.-Y. Faye A. Leechanachai P. Limtrakul A. Rugpao S. Sirivatanapa P. Gomuthbutra V. Matanasaravoot W. Le Coeur S. Lallemant M. Barre-Sinoussi F. Menu E. Ngo-Giang-Huong N. Ayouba A. Chailert S. Chaouat G. Derrien M. Dolcini G. Eteki N. Kfutwah A.J. Kouo O. Lemen B. Maldonado-Estrada J. Nerrienet E. Njinku B. Scarlatti G. Tejiokem M. Tene G. |
author_sort |
Pornprasert S. |
title |
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
title_short |
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
title_full |
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
title_fullStr |
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
title_full_unstemmed |
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
title_sort |
higher placental anti-inflammatory il-10 cytokine expression in hiv-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine |
publishDate |
2014 |
url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-64749097199&partnerID=40&md5=20c9efc3c607ff9233b90db77b0c4d47 http://www.ncbi.nlm.nih.gov/pubmed/19275589 http://cmuir.cmu.ac.th/handle/6653943832/776 |
_version_ |
1681419546804617216 |