Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women

• Main Authors: Cressey T.R., Van Dyke R., Jourdain G., Puthanakit T., Roongpisuthipong A., Achalapong J., Yuthavisuthi P., Prommas S., Chotivanich N., Maupin R., Smith E., Shapiro D.E., Mirochnick M.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-66149098490&partnerID=40&md5=5a45497e177f994e7ade742a58781835; http://cmuir.cmu.ac.th/handle/6653943832/778
• Institution: Chiang Mai University

Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the...