Identification of amino acid residues of a designed ankyrin repeat protein potentially involved in intermolecular interactions with CD4: Analysis by molecular dynamics simulations

• Main Authors: Nimmanpipug P., Khampa C., Lee V.S., Nangola S., Tayapiwatana C.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053909179&partnerID=40&md5=b2337f3969c45e8a838766af97665672; http://www.ncbi.nlm.nih.gov/pubmed/21962990; http://cmuir.cmu.ac.th/handle/6653943832/787

We applied molecular dynamics simulations to investigate the binding properties of a designed ankyrin repeat protein, the DARPin-CD4 complex. DARPin 23.2 has been reported to disturb the human immunodeficiency virus (HIV) viral entry process by Schweizer et al. The protein docking simulation was ana...