Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation

• Main Authors: Chiampanichayakul S., Szekeres A., Khunkaewla P., Moonsom S., Leksa V., Drbal K., Zlabinger GJ., Hofer-Warbinek R., Stockinger H., Kasinrerk W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/3502482; http://cmuir.cmu.ac.th/handle/6653943832/820
• Institution: Chiang Mai University

In order to identify new molecules involved in regulation of T cell proliferation, we generated various mAb by immunization of mice with the T cell line Molt4. We found one mAb (termed P-3E10) that down-regulated the in vitro T cell proliferation induced by CD3-specific OKT3 mAb. The P-3E10 mAb was...