Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy

Antibodies of IgM, IgG and IgA classes against M.leprae specific antigens (PGL-I, ND-O-BSA, and NT-O-BSA) were determined in the sera of 80 leprosy patients (28 untreated, 34 treated lepromatous and 18 tuberculoid), 25 tuberculosis patients and 33 normal individuals of Northern Thailand. No strong d...

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Main Authors: Praputpittaya K., Suriyanon V., Hirunpetcharat C., Rungruengthanakit K., Suphawilai C.
Format: Comparative Study
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/836
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-8362014-08-29T09:02:13Z Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy Praputpittaya K. Suriyanon V. Hirunpetcharat C. Rungruengthanakit K. Suphawilai C. Antibodies of IgM, IgG and IgA classes against M.leprae specific antigens (PGL-I, ND-O-BSA, and NT-O-BSA) were determined in the sera of 80 leprosy patients (28 untreated, 34 treated lepromatous and 18 tuberculoid), 25 tuberculosis patients and 33 normal individuals of Northern Thailand. No strong distinction in reactivity could be found between the three antigens. The IgM antibody assay yielded more positive results than assays for IgG and IgA. It was found that the positivity rates of IgM antibodies to all three antigens were highest in untreated lepromatous leprosy (82%). In tuberculoid leprosy, the positivity rates of IgM, IgG and IgA to the antigens were more variable, ranging from 22 to 50 percent. Patients with tuberculosis and normal individuals did not produce IgM antibodies against the antigens. The results suggested that the determination of IgM against the three antigens is a more sensitive and specific test for active leprosy than those of IgG and IgA. The relationship between the duration of treatment and IgM antibody levels in lepromatous leprosy (LL) was studied. Untreated LL patients had significantly higher IgM and IgA antibody levels than treated patients. There was no difference in IgG antibody levels between the two groups, and the levels of both groups were higher than normal controls. Serial determination of IgM antibodies in 7 LL patients revealed that treatment was strongly associated with progressive decrease in IgM antibody levels against all three antigens. 2014-08-29T09:02:13Z 2014-08-29T09:02:13Z 1990 Comparative Study 0125-877X 2203362 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/836 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Antibodies of IgM, IgG and IgA classes against M.leprae specific antigens (PGL-I, ND-O-BSA, and NT-O-BSA) were determined in the sera of 80 leprosy patients (28 untreated, 34 treated lepromatous and 18 tuberculoid), 25 tuberculosis patients and 33 normal individuals of Northern Thailand. No strong distinction in reactivity could be found between the three antigens. The IgM antibody assay yielded more positive results than assays for IgG and IgA. It was found that the positivity rates of IgM antibodies to all three antigens were highest in untreated lepromatous leprosy (82%). In tuberculoid leprosy, the positivity rates of IgM, IgG and IgA to the antigens were more variable, ranging from 22 to 50 percent. Patients with tuberculosis and normal individuals did not produce IgM antibodies against the antigens. The results suggested that the determination of IgM against the three antigens is a more sensitive and specific test for active leprosy than those of IgG and IgA. The relationship between the duration of treatment and IgM antibody levels in lepromatous leprosy (LL) was studied. Untreated LL patients had significantly higher IgM and IgA antibody levels than treated patients. There was no difference in IgG antibody levels between the two groups, and the levels of both groups were higher than normal controls. Serial determination of IgM antibodies in 7 LL patients revealed that treatment was strongly associated with progressive decrease in IgM antibody levels against all three antigens.
format Comparative Study
author Praputpittaya K.
Suriyanon V.
Hirunpetcharat C.
Rungruengthanakit K.
Suphawilai C.
spellingShingle Praputpittaya K.
Suriyanon V.
Hirunpetcharat C.
Rungruengthanakit K.
Suphawilai C.
Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
author_facet Praputpittaya K.
Suriyanon V.
Hirunpetcharat C.
Rungruengthanakit K.
Suphawilai C.
author_sort Praputpittaya K.
title Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
title_short Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
title_full Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
title_fullStr Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
title_full_unstemmed Comparison of IgM, IgG and IgA responses to M.leprae specific antigens in leprosy
title_sort comparison of igm, igg and iga responses to m.leprae specific antigens in leprosy
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/836
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