Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure

Objective: To measure bone mineral density in cadmium-exposed persons aged 40 years and older that lived in the 12 contaminated villages in northwestern Thailand. Material and Method: Five hundred seventy three persons with urinary cadmium levels ≥ 5 μg/g creatinine during the 2004-2006 surveys were...

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Main Authors: Limpatanachote P., Swaddiwudhipong W., Nishijo M., Honda R., Mahasakpan P., Nambunmee K., Ruangyuttikarn W.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-78650040743&partnerID=40&md5=5add62d44740b2676e0b4ac6d32ae688
http://cmuir.cmu.ac.th/handle/6653943832/848
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-8482014-08-29T09:02:14Z Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure Limpatanachote P. Swaddiwudhipong W. Nishijo M. Honda R. Mahasakpan P. Nambunmee K. Ruangyuttikarn W. Objective: To measure bone mineral density in cadmium-exposed persons aged 40 years and older that lived in the 12 contaminated villages in northwestern Thailand. Material and Method: Five hundred seventy three persons with urinary cadmium levels ≥ 5 μg/g creatinine during the 2004-2006 surveys were screened in 2007 for urinary excretion of cadmium, bone formation and resorption markers, and renal function markers. Calcaneus bone density was measured in each person by a dual-energy X-ray absorptiometry bone scanner. Results: The mean age of the study persons was 57 years old. The geometric mean level of urinary cadmium for women was significantly higher than that for men. Women had a lower mean of calcaneus bone density than men. The rate of osteoporosis in women (21.5%) was significantly higher than that for men (14.7%). Calcaneus bone density was negatively correlated with urinary excretion of calcium (in both genders) and crosslinked N-telopeptide of type I collagen (in women), after adjusting for other co-variables. Increasing urinary cadmium levels appeared to correlate with reduced bone density in women, but not in men. In both genders, urinary excretion of β2-microglobulin and N-acetyl-β-D-glucosaminidase was higher in persons with osteoporosis than those without. Conclusion: Bone mineral loss is correlated with urinary cadmium levels and renal dysfunction in this female population. 2014-08-29T09:02:14Z 2014-08-29T09:02:14Z 2010 Article 1252208 21344809 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-78650040743&partnerID=40&md5=5add62d44740b2676e0b4ac6d32ae688 http://cmuir.cmu.ac.th/handle/6653943832/848 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To measure bone mineral density in cadmium-exposed persons aged 40 years and older that lived in the 12 contaminated villages in northwestern Thailand. Material and Method: Five hundred seventy three persons with urinary cadmium levels ≥ 5 μg/g creatinine during the 2004-2006 surveys were screened in 2007 for urinary excretion of cadmium, bone formation and resorption markers, and renal function markers. Calcaneus bone density was measured in each person by a dual-energy X-ray absorptiometry bone scanner. Results: The mean age of the study persons was 57 years old. The geometric mean level of urinary cadmium for women was significantly higher than that for men. Women had a lower mean of calcaneus bone density than men. The rate of osteoporosis in women (21.5%) was significantly higher than that for men (14.7%). Calcaneus bone density was negatively correlated with urinary excretion of calcium (in both genders) and crosslinked N-telopeptide of type I collagen (in women), after adjusting for other co-variables. Increasing urinary cadmium levels appeared to correlate with reduced bone density in women, but not in men. In both genders, urinary excretion of β2-microglobulin and N-acetyl-β-D-glucosaminidase was higher in persons with osteoporosis than those without. Conclusion: Bone mineral loss is correlated with urinary cadmium levels and renal dysfunction in this female population.
format Article
author Limpatanachote P.
Swaddiwudhipong W.
Nishijo M.
Honda R.
Mahasakpan P.
Nambunmee K.
Ruangyuttikarn W.
spellingShingle Limpatanachote P.
Swaddiwudhipong W.
Nishijo M.
Honda R.
Mahasakpan P.
Nambunmee K.
Ruangyuttikarn W.
Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
author_facet Limpatanachote P.
Swaddiwudhipong W.
Nishijo M.
Honda R.
Mahasakpan P.
Nambunmee K.
Ruangyuttikarn W.
author_sort Limpatanachote P.
title Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
title_short Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
title_full Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
title_fullStr Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
title_full_unstemmed Cadmium-exposed population in Mae sot district, Tak province: 4 bone mineral density in persons with high cadmium exposure
title_sort cadmium-exposed population in mae sot district, tak province: 4 bone mineral density in persons with high cadmium exposure
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-78650040743&partnerID=40&md5=5add62d44740b2676e0b4ac6d32ae688
http://cmuir.cmu.ac.th/handle/6653943832/848
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