Quercetin, quercetrin except rutin potentially increased pirarubicin cytotoxicity by non-competitively inhibiting the P-glycoprotein-and MRP1 function in living K562/adr and GLC4/adr cells

• Main Authors: Choiprasert W., Dechsupa N., Kothan S., Garrigos M., Mankhetkorn S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949890664&partnerID=40&md5=0c51ddb5f21f4d987fa31532451a221e; http://cmuir.cmu.ac.th/handle/6653943832/865
• Institution: Chiang Mai University

Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combin...