Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity

• Main Authors: Sripetchwandee J., Pipatpiboon N., Chattipakorn N., Chattipakorn S.
• Format: Article
• Language: English
• Published: Public Library of Science 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84896460432&partnerID=40&md5=3074f17c9b24395413d19a3cc2d50db9; http://cmuir.cmu.ac.th/handle/6653943832/988
• Institution: Chiang Mai University

Background: Excessive iron accumulation leads to iron toxicity in the brain; however the underlying mechanism is unclear. We investigated the effects of iron overload induced by high iron-diet consumption on brain mitochondrial function, brain synaptic plasticity and learning and memory. Iron chelat...