Development and Regression of Murine Leukemia Induced by Friend Virus Complex
Injection of a large dose (5000 FFU) of Friend virus complex (FV) lead to rapid development of leukemia and to death in A/J mice. Leukemia developed at a slower rate in A/J mice inoculated with 5 FFU of FV. A very small dose (0.5 FFU) of the same virus caused slow development of leukemia that later...
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| Main Authors: | , |
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| Format: | Article |
| Published: |
2018
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| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/10114 |
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| Institution: | Mahidol University |
| Summary: | Injection of a large dose (5000 FFU) of Friend virus complex (FV) lead to rapid development of leukemia and to death in A/J mice. Leukemia developed at a slower rate in A/J mice inoculated with 5 FFU of FV. A very small dose (0.5 FFU) of the same virus caused slow development of leukemia that later regressed in most A/J mice (73%). In (A/J X C57BL/6J) F 1 and their reciprocal hybrids, leukemia developed rapidly after the injection of 500 FFU, but regressed in 97% of the mice. © 1973, SAGE Publications. All rights reserved. |
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