Control trial of soil-transmitted helminthic infections with pyrantel pamoate
Pyrantel pamoate at dosage of 10 mg/kg body weight was given to each subject at 4-6 week intervals on three occasions. The infection rates of hookworms among both those who received the treatment and those who did not decreased from 60.5% pre-treatment to 19.6% after the third treatment and then inc...
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th-mahidol.102752018-03-22T16:29:37Z Control trial of soil-transmitted helminthic infections with pyrantel pamoate M. Bhaibulaya V. Punnavutti S. Yamput S. Indra-Ngarm W. Pahuchon S. Hongsuwan S. Vajrasthira C. Harinasuta Mahidol University Medicine Pyrantel pamoate at dosage of 10 mg/kg body weight was given to each subject at 4-6 week intervals on three occasions. The infection rates of hookworms among both those who received the treatment and those who did not decreased from 60.5% pre-treatment to 19.6% after the third treatment and then increased to 32.4% by one year after the third treatment. Infection rates of A. lumbricoides and Strongyloides among the villagers who received and did not receive the drug decreased from 27.5% pre-treatment to 2.2% after the third treatment and then increased to 20.1% one year later for the former, while the latter decreased from 6.5% pre-treatment to 2.3% after the third treatment and 0.4% one year later. The infection rate of T. trichiura was found to increase as pyrantel pamoate had no effect on this nematode. The authors suggested that to obtain more satisfactory results the anthelmintic drug used must likewise be effective against T. trichiura particularly in areas where this nematode is a public health problem. It was also suggested that the duration of treatment should be prolonged. 2018-03-22T09:29:37Z 2018-03-22T09:29:37Z 1977-12-01 Article Southeast Asian Journal of Tropical Medicine and Public Health. Vol.8, No.3 (1977), 329-334 00383619 2-s2.0-0017587045 https://repository.li.mahidol.ac.th/handle/123456789/10275 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017587045&origin=inward |
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Medicine M. Bhaibulaya V. Punnavutti S. Yamput S. Indra-Ngarm W. Pahuchon S. Hongsuwan S. Vajrasthira C. Harinasuta Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
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Pyrantel pamoate at dosage of 10 mg/kg body weight was given to each subject at 4-6 week intervals on three occasions. The infection rates of hookworms among both those who received the treatment and those who did not decreased from 60.5% pre-treatment to 19.6% after the third treatment and then increased to 32.4% by one year after the third treatment. Infection rates of A. lumbricoides and Strongyloides among the villagers who received and did not receive the drug decreased from 27.5% pre-treatment to 2.2% after the third treatment and then increased to 20.1% one year later for the former, while the latter decreased from 6.5% pre-treatment to 2.3% after the third treatment and 0.4% one year later. The infection rate of T. trichiura was found to increase as pyrantel pamoate had no effect on this nematode. The authors suggested that to obtain more satisfactory results the anthelmintic drug used must likewise be effective against T. trichiura particularly in areas where this nematode is a public health problem. It was also suggested that the duration of treatment should be prolonged. |
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Mahidol University |
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Mahidol University M. Bhaibulaya V. Punnavutti S. Yamput S. Indra-Ngarm W. Pahuchon S. Hongsuwan S. Vajrasthira C. Harinasuta |
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M. Bhaibulaya V. Punnavutti S. Yamput S. Indra-Ngarm W. Pahuchon S. Hongsuwan S. Vajrasthira C. Harinasuta |
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M. Bhaibulaya |
title |
Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
title_short |
Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
title_full |
Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
title_fullStr |
Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
title_full_unstemmed |
Control trial of soil-transmitted helminthic infections with pyrantel pamoate |
title_sort |
control trial of soil-transmitted helminthic infections with pyrantel pamoate |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/10275 |
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1763489496449417216 |