DIFFERENTIATION OF METABOLIC ADRENOCEPTORS
Cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg −1 min −1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolo...
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th-mahidol.103372018-03-22T16:30:54Z DIFFERENTIATION OF METABOLIC ADRENOCEPTORS T. LOAKPRADIT R. LOCKWOOD Mahidol University Pharmacology, Toxicology and Pharmaceutics Cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg −1 min −1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non‐selectively. Para‐oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on heart rate and free fatty acids selectively. H 35/25 ((1‐(4‐methylphenyl)‐2‐isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively. It is concluded that metabolic adrenoceptors are differentiated into subtypes similar to those mediating cardiostimulation and vasodilatation. 1977 British Pharmacological Society 2018-03-22T09:30:54Z 2018-03-22T09:30:54Z 1977-01-01 Article British Journal of Pharmacology. Vol.59, No.1 (1977), 135-140 10.1111/j.1476-5381.1977.tb06987.x 14765381 00071188 2-s2.0-0017365208 https://repository.li.mahidol.ac.th/handle/123456789/10337 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017365208&origin=inward |
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Pharmacology, Toxicology and Pharmaceutics |
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Pharmacology, Toxicology and Pharmaceutics T. LOAKPRADIT R. LOCKWOOD DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
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Cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg −1 min −1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non‐selectively. Para‐oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on heart rate and free fatty acids selectively. H 35/25 ((1‐(4‐methylphenyl)‐2‐isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively. It is concluded that metabolic adrenoceptors are differentiated into subtypes similar to those mediating cardiostimulation and vasodilatation. 1977 British Pharmacological Society |
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Mahidol University |
| author_facet |
Mahidol University T. LOAKPRADIT R. LOCKWOOD |
| format |
Article |
| author |
T. LOAKPRADIT R. LOCKWOOD |
| author_sort |
T. LOAKPRADIT |
| title |
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
| title_short |
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
| title_full |
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
| title_fullStr |
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
| title_full_unstemmed |
DIFFERENTIATION OF METABOLIC ADRENOCEPTORS |
| title_sort |
differentiation of metabolic adrenoceptors |
| publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/10337 |
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1763494205751033856 |