Selective activation of cardiovascular adenylate cyclase in vivo
Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 μg/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretr...
Saved in:
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/10338 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Mahidol University |
| id |
th-mahidol.10338 |
|---|---|
| record_format |
dspace |
| spelling |
th-mahidol.103382018-03-22T16:30:55Z Selective activation of cardiovascular adenylate cyclase in vivo S. Phornchirasilp R. Lockwood Mahidol University Pharmacology, Toxicology and Pharmaceutics Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 μg/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretreatment with phenoxybenzamine, 1 mg/kg i.v. Tazolol, 120 μg/kg i.v., selectively increased cardiac cyclic AMP levels whereas fenoterol, 15 μg/kg i.v., selectively increased vascular cyclic AMP levels. The results suggest that adenylate cyclase activation in cardiac and vascular tissues in vivo is mediated by beta adrenoceptors which consist of different subtypes. 2018-03-22T09:30:55Z 2018-03-22T09:30:55Z 1977-01-01 Article Archives Internationales de Pharmacodynamie et de Therapie. Vol.225, No.1 (1977), 98-103 00039780 2-s2.0-0017326382 https://repository.li.mahidol.ac.th/handle/123456789/10338 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017326382&origin=inward |
| institution |
Mahidol University |
| building |
Mahidol University Library |
| continent |
Asia |
| country |
Thailand Thailand |
| content_provider |
Mahidol University Library |
| collection |
Mahidol University Institutional Repository |
| topic |
Pharmacology, Toxicology and Pharmaceutics |
| spellingShingle |
Pharmacology, Toxicology and Pharmaceutics S. Phornchirasilp R. Lockwood Selective activation of cardiovascular adenylate cyclase in vivo |
| description |
Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 μg/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretreatment with phenoxybenzamine, 1 mg/kg i.v. Tazolol, 120 μg/kg i.v., selectively increased cardiac cyclic AMP levels whereas fenoterol, 15 μg/kg i.v., selectively increased vascular cyclic AMP levels. The results suggest that adenylate cyclase activation in cardiac and vascular tissues in vivo is mediated by beta adrenoceptors which consist of different subtypes. |
| author2 |
Mahidol University |
| author_facet |
Mahidol University S. Phornchirasilp R. Lockwood |
| format |
Article |
| author |
S. Phornchirasilp R. Lockwood |
| author_sort |
S. Phornchirasilp |
| title |
Selective activation of cardiovascular adenylate cyclase in vivo |
| title_short |
Selective activation of cardiovascular adenylate cyclase in vivo |
| title_full |
Selective activation of cardiovascular adenylate cyclase in vivo |
| title_fullStr |
Selective activation of cardiovascular adenylate cyclase in vivo |
| title_full_unstemmed |
Selective activation of cardiovascular adenylate cyclase in vivo |
| title_sort |
selective activation of cardiovascular adenylate cyclase in vivo |
| publishDate |
2018 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/10338 |
| _version_ |
1763498132023279616 |