Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP
Distribution of populations of the opportunistic black yeast Exophiala dermatitidis was studied using AFLP. This fungus has been hypothesized to have a natural habitat in association with frugivorous birds and bats in the tropical rain forest, and to emerge in the human-dominated environment, where...
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th-mahidol.112632018-05-03T15:25:32Z Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP Montarop Sudhadham A. H G Gerrits Van Den Ende P. Sihanonth S. Sivichai R. Chaiyarat S. B J Menken A. Van Belkum G. S. De Hoog CBS Fungal Biodiversity Center CBS - KNAW University of Amsterdam Chulalongkorn University Thailand National Center for Genetic Engineering and Biotechnology Mahidol University Erasmus University Medical Center Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Medicine Distribution of populations of the opportunistic black yeast Exophiala dermatitidis was studied using AFLP. This fungus has been hypothesized to have a natural habitat in association with frugivorous birds and bats in the tropical rain forest, and to emerge in the human-dominated environment, where it occasionally causes human pulmonary or fatal disseminated and neurotropic disease. The hypothesis of its natural niche was investigated by comparing a set of 178 strains from natural and human-dominated environments in Thailand with a worldwide selection of 107 strains from the reference collection of the CBS Fungal Biodiversity Centre, comprising 75.7. % clinical isolates. Many isolates had unique AFLP patterns and were too remote for confident comparison. Eight populations containing multiple isolates could be distinguished, enabling determination of geographic distributions of these populations. Some of the populations were confined to Thailand, while others occurred worldwide. The local populations from Thailand contained strains from natural and urban environments, suggesting an environmental jump of the fungus. Strains from human brain belonged to widely dispersed populations. In some cases cerebral isolates were identical to isolates from the human intestinal tract. The possibility of cerebral infection through intestinal translocation was thus not excluded. © 2010 British Mycological Society. 2018-05-03T07:55:37Z 2018-05-03T07:55:37Z 2011-10-01 Article Fungal Biology. Vol.115, No.10 (2011), 1051-1065 10.1016/j.funbio.2010.07.004 18786146 2-s2.0-79952333381 https://repository.li.mahidol.ac.th/handle/123456789/11263 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952333381&origin=inward |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Medicine Montarop Sudhadham A. H G Gerrits Van Den Ende P. Sihanonth S. Sivichai R. Chaiyarat S. B J Menken A. Van Belkum G. S. De Hoog Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
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Distribution of populations of the opportunistic black yeast Exophiala dermatitidis was studied using AFLP. This fungus has been hypothesized to have a natural habitat in association with frugivorous birds and bats in the tropical rain forest, and to emerge in the human-dominated environment, where it occasionally causes human pulmonary or fatal disseminated and neurotropic disease. The hypothesis of its natural niche was investigated by comparing a set of 178 strains from natural and human-dominated environments in Thailand with a worldwide selection of 107 strains from the reference collection of the CBS Fungal Biodiversity Centre, comprising 75.7. % clinical isolates. Many isolates had unique AFLP patterns and were too remote for confident comparison. Eight populations containing multiple isolates could be distinguished, enabling determination of geographic distributions of these populations. Some of the populations were confined to Thailand, while others occurred worldwide. The local populations from Thailand contained strains from natural and urban environments, suggesting an environmental jump of the fungus. Strains from human brain belonged to widely dispersed populations. In some cases cerebral isolates were identical to isolates from the human intestinal tract. The possibility of cerebral infection through intestinal translocation was thus not excluded. © 2010 British Mycological Society. |
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CBS Fungal Biodiversity Center CBS - KNAW |
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CBS Fungal Biodiversity Center CBS - KNAW Montarop Sudhadham A. H G Gerrits Van Den Ende P. Sihanonth S. Sivichai R. Chaiyarat S. B J Menken A. Van Belkum G. S. De Hoog |
format |
Article |
author |
Montarop Sudhadham A. H G Gerrits Van Den Ende P. Sihanonth S. Sivichai R. Chaiyarat S. B J Menken A. Van Belkum G. S. De Hoog |
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Montarop Sudhadham |
title |
Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
title_short |
Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
title_full |
Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
title_fullStr |
Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
title_full_unstemmed |
Elucidation of distribution patterns and possible infection routes of the neurotropic black yeast Exophiala dermatitidis using AFLP |
title_sort |
elucidation of distribution patterns and possible infection routes of the neurotropic black yeast exophiala dermatitidis using aflp |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/11263 |
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1763488554393010176 |