Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis

Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crysta...

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Main Authors:	Thitima Lhinhatrakool, Samran Prabpai, Palangpon Kongsaeree, Somyote Sutthivaiyakit
Other Authors:	Ramkhamhaeng University
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/11530
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Institution:	Mahidol University

id	th-mahidol.11530
record_format	dspace
spelling	th-mahidol.115302018-05-03T15:42:03Z Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis Thitima Lhinhatrakool Samran Prabpai Palangpon Kongsaeree Somyote Sutthivaiyakit Ramkhamhaeng University Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy. 2018-05-03T08:02:03Z 2018-05-03T08:02:03Z 2011-06-24 Article Journal of Natural Products. Vol.74, No.6 (2011), 1386-1391 10.1021/np200014k 15206025 01633864 2-s2.0-79959726526 https://repository.li.mahidol.ac.th/handle/123456789/11530 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959726526&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Thitima Lhinhatrakool Samran Prabpai Palangpon Kongsaeree Somyote Sutthivaiyakit Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
description	Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy.
author2	Ramkhamhaeng University
author_facet	Ramkhamhaeng University Thitima Lhinhatrakool Samran Prabpai Palangpon Kongsaeree Somyote Sutthivaiyakit
format	Article
author	Thitima Lhinhatrakool Samran Prabpai Palangpon Kongsaeree Somyote Sutthivaiyakit
author_sort	Thitima Lhinhatrakool
title	Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
title_short	Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
title_full	Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
title_fullStr	Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
title_full_unstemmed	Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
title_sort	antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/11530
_version_	1763495085991788544

Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis

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