Overcoming multidrug resistance in human lung cancer with novel benzo[a]quinolizin-4-ones

Overcoming multidrug resistance in human lung cancer with novel benzo[a]quinolizin-4-ones

Aim: To investigate the ability of synthetic benzo[a]quinolizin-4-one derivatives to reverse multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with MDR, A5 49RT-eto, was established by exposure to 1.5 μM etoposide. Cytotoxic activity was assayed by the 3-(4,5-dimeth...

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Main Authors: Yodsoi Kanintronkul, Rattana Worayuthakarn, Nopporn Thasana, Pakorn Winayanuwattikun, Kovit Pattanapanyasat, Rudee Surarit, Somsak Ruchirawat, Jisnuson Svasti
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/11585
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/11585

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