Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.

Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.

Five known isocoumarins, monocerin (1), derivative 2, and fusarentin derivatives 3-5, and a new phthalide (6) were isolated from the endophytic fungus Colletotrichum sp. 2 selectively exhibited cytotoxic activity toward the HepG2 cell line. Compounds 2 and 4 scavenged 2,2-diphenyl-1-picrylhydrazyl (...

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Bibliographic Details
Main Authors: Kamolchanok Tianpanich, Surasak Prachya, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Other Authors: Center for Environmental Health
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/11602
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Institution: Mahidol University
Description
Summary:Five known isocoumarins, monocerin (1), derivative 2, and fusarentin derivatives 3-5, and a new phthalide (6) were isolated from the endophytic fungus Colletotrichum sp. 2 selectively exhibited cytotoxic activity toward the HepG2 cell line. Compounds 2 and 4 scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals (IC50 values of 23.4 and 16.4 μM, respectively) and inhibited superoxide anion radical formation (IC50 values of 52.6 and 4.3 μM, respectively). The C-7 hydroxyl group in 2 and 4 might be important for radical scavenging activities. Isocoumarins 1-3 and phthalide 6 showed p otent antioxidant activity. © 2011 American Chemical Society and American Society of Pharmacognosy.

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