Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following infection with Dengue Virus

• Main Authors: Natthanej Luplertlop, Pornapat Surasombatpattana, Degrees Patramool, Emilie Dumas, Ladawan Wasinpiyamongkol, Laure Saune, Rodolphe Hamel, Eric Bernard, Denis Sereno, Frédé Ric Thomas, David Piquemal, Hans Yssel, Laurence Briant, Dorothée Missé
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11641

The ultimate stage of the transmission of Dengue Virus (DENV) to man is strongly dependent on crosstalk between the virus and the immune system of its vector Aedes aegypti (Ae. aegypti). Infection of the mosquito's salivary glands by DENV is the final step prior to viral transmission. Therefore...