A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole

A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole

The construction of a new pentacyclic ring system, 6,7,14,15-tetrahydro[1, 5]diazocino[1,2-a:6,5-a'] -8-dihydrodiindole (7) from simple precursors through our new synthetic route was presented to be a facile and concise method for an intramolecular N-alkylation of tosylate 12 which was obtained...

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Main Authors: Kittisak Sripha, Darius Paul Zlotos, Ulrike Holzgrabe, Somsak Ruchirawat
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/11689
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spelling th-mahidol.116892018-05-03T15:41:14Z A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole Kittisak Sripha Darius Paul Zlotos Ulrike Holzgrabe Somsak Ruchirawat Mahidol University Julius-Maximilians-Universitat Wurzburg Chulabhorn Research Institute Chemistry Pharmacology, Toxicology and Pharmaceutics The construction of a new pentacyclic ring system, 6,7,14,15-tetrahydro[1, 5]diazocino[1,2-a:6,5-a'] -8-dihydrodiindole (7) from simple precursors through our new synthetic route was presented to be a facile and concise method for an intramolecular N-alkylation of tosylate 12 which was obtained from N-acylation of indoline 4 with indole acid 9, followed by reduction and tosylation. This new synthetic approach can overcome the disadvantage of uncontrollable intermolecular double N-alkylation of the precursor 3 to produce the unexpected ring system 2. © 2011 The Japan Institute of Heterocyclic Chemistry. 2018-05-03T08:06:30Z 2018-05-03T08:06:30Z 2011-10-31 Article Heterocycles. Vol.83, No.11 (2011), 2627-2633 10.3987/COM-11-12340 18810942 03855414 2-s2.0-80455125913 https://repository.li.mahidol.ac.th/handle/123456789/11689 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80455125913&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemistry
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Chemistry
Pharmacology, Toxicology and Pharmaceutics
Kittisak Sripha
Darius Paul Zlotos
Ulrike Holzgrabe
Somsak Ruchirawat
A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
description The construction of a new pentacyclic ring system, 6,7,14,15-tetrahydro[1, 5]diazocino[1,2-a:6,5-a'] -8-dihydrodiindole (7) from simple precursors through our new synthetic route was presented to be a facile and concise method for an intramolecular N-alkylation of tosylate 12 which was obtained from N-acylation of indoline 4 with indole acid 9, followed by reduction and tosylation. This new synthetic approach can overcome the disadvantage of uncontrollable intermolecular double N-alkylation of the precursor 3 to produce the unexpected ring system 2. © 2011 The Japan Institute of Heterocyclic Chemistry.
author2 Mahidol University
author_facet Mahidol University
Kittisak Sripha
Darius Paul Zlotos
Ulrike Holzgrabe
Somsak Ruchirawat
format Article
author Kittisak Sripha
Darius Paul Zlotos
Ulrike Holzgrabe
Somsak Ruchirawat
author_sort Kittisak Sripha
title A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
title_short A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
title_full A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
title_fullStr A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
title_full_unstemmed A new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
title_sort new synthetic approach to pentacyclic ring, 6,7,14,15-tetrahydro[1,5] diazocino[1,2-a:6,5-a']-8-dihydrodiindole
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/11689
_version_ 1763487799400464384

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