Impairment of CD4CD25+ regulatory T cells in C4-deficient mice

• Main Authors: Pornsawan Leaungwutiwong, Wannaporn Ittiprasert, Kulnasan Saikhun, Pirut Tong-Ngam, Siriwat Akapirat, Siriporn Chattanadee, Yindee Kitiyanant
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11989

Objective: To investigate the association between deficiencies of early components in the classical complement pathway and the development of SLE. Methods: Forty inbred C57BL/6J mice and 40 knockout C4 complement gene (C4KO) mice, which included 10 mice in each age group (2, 4, 6, and 8 months) were...