Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital
A total of 83 Acinetobacter baumannii isolates from patients attending a tertiary care university hospital in Thailand were investigated for their clonal relatedness, antimicrobial susceptibility profiles, and integron carriage. Susceptibility profiles showed that 56 (67%) of these isolates exhibite...
Saved in:
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/12076 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.12076 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.120762018-05-03T15:42:44Z Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital Palpasa Kansakar Dorji Dorji Piriyaporn Chongtrakool Sirima Mingmongkolchai Benjaporn Mokmake Padungsri Dubbs Mahidol University Jigme Dorji Wangchuk National Referral Hospital Immunology and Microbiology Medicine Pharmacology, Toxicology and Pharmaceutics A total of 83 Acinetobacter baumannii isolates from patients attending a tertiary care university hospital in Thailand were investigated for their clonal relatedness, antimicrobial susceptibility profiles, and integron carriage. Susceptibility profiles showed that 56 (67%) of these isolates exhibited multiple drug resistance (MDR). Pulsed-field gel electrophoresis (PFGE) showed that 73% of these resistant isolates were clustered into three predominant PFGE types: 6, 7, and 36. This suggested that the high number of isolates exhibiting MDR phenotypes observed in the hospital is, to some extent, due to the spread of these three resistant clones. Class 1 integrase genes were detected in all MDR isolates belonging to PFGE type 6, most MDR isolates belonging to PFGE type 7 and none of the isolates belonging to PFGE type 36. Five different class 1 gene cassette arrays, dfrA1-orfC, bla IMP-14 -aac6′, aacA4- catB8-aadA1, aacC1-orfX-orfX′-aadA1a, and aacC1-orfX-orfX-orfX′- aadA1a, were identified, of which the bla IMP-14 -aac6′ array has only been found in Thai isolates. Two isolates identified in this study carried a class 2 integrase gene with a 2.2 kb cassette array containing aadA1-sat-dfrA1. Copyright © 2011, Mary Ann Liebert, Inc. 2018-05-03T08:17:23Z 2018-05-03T08:17:23Z 2011-03-01 Article Microbial Drug Resistance. Vol.17, No.1 (2011), 109-119 10.1089/mdr.2010.0062 10766294 2-s2.0-79952372430 https://repository.li.mahidol.ac.th/handle/123456789/12076 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952372430&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Immunology and Microbiology Medicine Pharmacology, Toxicology and Pharmaceutics |
spellingShingle |
Immunology and Microbiology Medicine Pharmacology, Toxicology and Pharmaceutics Palpasa Kansakar Dorji Dorji Piriyaporn Chongtrakool Sirima Mingmongkolchai Benjaporn Mokmake Padungsri Dubbs Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
description |
A total of 83 Acinetobacter baumannii isolates from patients attending a tertiary care university hospital in Thailand were investigated for their clonal relatedness, antimicrobial susceptibility profiles, and integron carriage. Susceptibility profiles showed that 56 (67%) of these isolates exhibited multiple drug resistance (MDR). Pulsed-field gel electrophoresis (PFGE) showed that 73% of these resistant isolates were clustered into three predominant PFGE types: 6, 7, and 36. This suggested that the high number of isolates exhibiting MDR phenotypes observed in the hospital is, to some extent, due to the spread of these three resistant clones. Class 1 integrase genes were detected in all MDR isolates belonging to PFGE type 6, most MDR isolates belonging to PFGE type 7 and none of the isolates belonging to PFGE type 36. Five different class 1 gene cassette arrays, dfrA1-orfC, bla IMP-14 -aac6′, aacA4- catB8-aadA1, aacC1-orfX-orfX′-aadA1a, and aacC1-orfX-orfX-orfX′- aadA1a, were identified, of which the bla IMP-14 -aac6′ array has only been found in Thai isolates. Two isolates identified in this study carried a class 2 integrase gene with a 2.2 kb cassette array containing aadA1-sat-dfrA1. Copyright © 2011, Mary Ann Liebert, Inc. |
author2 |
Mahidol University |
author_facet |
Mahidol University Palpasa Kansakar Dorji Dorji Piriyaporn Chongtrakool Sirima Mingmongkolchai Benjaporn Mokmake Padungsri Dubbs |
format |
Article |
author |
Palpasa Kansakar Dorji Dorji Piriyaporn Chongtrakool Sirima Mingmongkolchai Benjaporn Mokmake Padungsri Dubbs |
author_sort |
Palpasa Kansakar |
title |
Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
title_short |
Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
title_full |
Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
title_fullStr |
Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
title_full_unstemmed |
Local dissemination of multidrug-resistant acinetobacter baumannii clones in a Thai Hospital |
title_sort |
local dissemination of multidrug-resistant acinetobacter baumannii clones in a thai hospital |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/12076 |
_version_ |
1763487221495627776 |