Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia
We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial gen...
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th-mahidol.120852018-05-03T15:36:45Z Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia Emma K. Nickerson Vanaporn Wuthiekanun Varun Kumar Premjit Amornchai Nattavut Wongdeethai Kheng Chheng Narisara Chantratita Hor Putchhat Janjira Thaipadungpanit Nicholas P. Day Sharon J. Peacock Addenbrooke's Hospital Mahidol University Angkor Hospital for Children University of Cambridge Immunology and Microbiology Medicine We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial genotypes by using pulsed-field gel electrophoresis and multilocus sequence typing. A prospective cohort study of MRSA carriage conducted over one month at the Angkor Hospital for Children, Siem Reap, Cambodia, identified MRSA carriage in 87 (3.5%) of 2,485 children who came to the outpatient department, and 6 (4.1%) of 145 inpatients, including at least two with cases of nosocomial acquisition. Genotyping of all 93 MRSA isolates resolved 5 genotypes. Most (91%) isolates were assigned to sequence type 834. Only 28 (32%) of 87 MRSA carriers identified in the outpatient department had no history of recent healthcare contact. The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene. 2018-05-03T08:17:42Z 2018-05-03T08:17:42Z 2011-02-01 Article American Journal of Tropical Medicine and Hygiene. Vol.84, No.2 (2011), 313-317 10.4269/ajtmh.2011.10-0300 00029637 2-s2.0-79952642163 https://repository.li.mahidol.ac.th/handle/123456789/12085 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952642163&origin=inward |
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Immunology and Microbiology Medicine Emma K. Nickerson Vanaporn Wuthiekanun Varun Kumar Premjit Amornchai Nattavut Wongdeethai Kheng Chheng Narisara Chantratita Hor Putchhat Janjira Thaipadungpanit Nicholas P. Day Sharon J. Peacock Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
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We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial genotypes by using pulsed-field gel electrophoresis and multilocus sequence typing. A prospective cohort study of MRSA carriage conducted over one month at the Angkor Hospital for Children, Siem Reap, Cambodia, identified MRSA carriage in 87 (3.5%) of 2,485 children who came to the outpatient department, and 6 (4.1%) of 145 inpatients, including at least two with cases of nosocomial acquisition. Genotyping of all 93 MRSA isolates resolved 5 genotypes. Most (91%) isolates were assigned to sequence type 834. Only 28 (32%) of 87 MRSA carriers identified in the outpatient department had no history of recent healthcare contact. The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene. |
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Addenbrooke's Hospital |
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Addenbrooke's Hospital Emma K. Nickerson Vanaporn Wuthiekanun Varun Kumar Premjit Amornchai Nattavut Wongdeethai Kheng Chheng Narisara Chantratita Hor Putchhat Janjira Thaipadungpanit Nicholas P. Day Sharon J. Peacock |
format |
Article |
author |
Emma K. Nickerson Vanaporn Wuthiekanun Varun Kumar Premjit Amornchai Nattavut Wongdeethai Kheng Chheng Narisara Chantratita Hor Putchhat Janjira Thaipadungpanit Nicholas P. Day Sharon J. Peacock |
author_sort |
Emma K. Nickerson |
title |
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
title_short |
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
title_full |
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
title_fullStr |
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
title_full_unstemmed |
Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia |
title_sort |
emergence of community-associated methicillin-resistant staphylococcus aureus carriage in children in cambodia |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/12085 |
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1763488814171422720 |