In vitro pharmacodynamics of simulated pulmonary exposures of tigecycline alone and in combination against Klebsiella pneumoniae isolates producing a KPC carbapenemase

Multidrug-resistant Klebsiella pneumoniae strains that produce a serine carbapenemase (KPC) are emerging worldwide, with few therapeutic options that retain consistent susceptibility. The objective of this study was to determine the effect of combination therapy with tigecycline versus tigecycline a...

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Bibliographic Details
Main Authors: Dora E. Wiskirchen, Pornpan Koomanachai, Anthony M. Nicasio, David P. Nicolau, Joseph L. Kuti
Other Authors: Hartford Hospital
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/12570
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Institution: Mahidol University