Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax

Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax

Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium v...

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Bibliographic Details
Main Authors: Mallika Imwong, Bruce Russell, Rossarin Suwanarusk, Alexis Nzila, Mara L. Leimanis, Kanlaya Sriprawat, Supaporn Kaewpongsri, Aung Pyae Phyo, Georges Snounou, Francois Nosten, Laurent Renia
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/12700
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Institution: Mahidol University

Internet

https://repository.li.mahidol.ac.th/handle/123456789/12700

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