Loss of astrocyte polarization in the Tg-ArcSwe mouse model of Alzheimer's disease

• Main Authors: Jing Yang, Lisa K. Lunde, Paworn Nuntagij, Tomohiro Oguchi, Laura M.A. Camassa, Lars N.G. Nilsson, Lars Lannfelt, Yuming Xu, Mahmood Amiry-Moghaddam, Ole Petter Ottersen, Reidun Torp
• Other Authors: First Affiliated Hospital of Zhengzhou University
• Format: Article
• Published: 2018
• Subjects: Medicine; Psychology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12776
• Institution: Mahidol University

Aquaporin-4 (AQP4) is the predominant water channel in brain and is selectively expressed in astrocytes. Astrocytic endfoot membranes exhibit tenfold higher densities of AQP4 than non-endfoot membranes, making AQP4 an excellent marker of astrocyte polarization. Loss of astrocyte polarization is know...