Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids

• Main Authors: C. Thephinlap, C. Phisalaphong, N. Lailerd, N. Chattipakorn, P. Winichagoon, J. Vadolus, S. Fucharoen, J. B. Porter, S. Srichairatanakool
• Other Authors: Chiang Mai University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12835
• Institution: Mahidol University

Non-transferrin bound iron (NTBI) is found in plasma of β-thalassemia patients and causes oxidative tissue damage. Cardiac siderosis and complications are the secondary cause of death in β-thalassemia major patients. Desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) are promising chelat...