Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis

• Main Authors: Takaaki Matsui, Siripong Thitamadee, Tomoko Murata, Hisaya Kakinuma, Takuji Nabetani, Yoshio Hirabayashi, Yoshikazu Hirate, Hitoshi Okamotob, Yasumasa Bessho
• Other Authors: Nara Institute of Science and Technology
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12917
• Institution: Mahidol University

The assembly of progenitor cells is a crucial step for organ formation during vertebrate development. Kupffer's vesicle (KV), a key organ required for the left-right asymmetric body plan in zebrafish, is generated from a cluster of ∼20 dorsal forerunner cells (DFCs). Although several genes are...