Intrahost modeling of artemisinin resistance in Plasmodium falciparum

• Main Authors: Sompob Saralamba, Wirichada Pan-Ngum, Richard J. Maude, Sue J. Lee, Joel Tarning, Niklas Lindegårdh, Kesinee Chotivanich, François Nosten, Nicholas P J Day, Duong Socheat, Nicholas J. White, Arjen M. Dondorp, Lisa J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12923

Artemisinin-resistant Plasmodium falciparum malaria has emerged in western Cambodia. Resistance is characterized by prolonged in vivo parasite clearance times (PCTs) following artesunate treatment. The biological basis is unclear. The hypothesis that delayed parasite clearance results from a stage-s...