The monthly injectable contraceptive: A two year clinical trial

A contraceptive regimen of monthly intramuscular injections of a combination of 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate (Cyclo-Provera, Upjohn Co, Kalamazoo, MI, USA) was studied in 111 Thai women through 2356 cycles. During the first two years of treatment, more than 80...

Full description

Saved in:
Bibliographic Details
Main Authors: S. Koetsawang, S. Srisupandit, O. Kiriwat, A. Koetsawang
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/13120
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.13120
record_format dspace
spelling th-mahidol.131202018-06-01T13:27:18Z The monthly injectable contraceptive: A two year clinical trial S. Koetsawang S. Srisupandit O. Kiriwat A. Koetsawang Mahidol University Medicine A contraceptive regimen of monthly intramuscular injections of a combination of 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate (Cyclo-Provera, Upjohn Co, Kalamazoo, MI, USA) was studied in 111 Thai women through 2356 cycles. During the first two years of treatment, more than 80% of the patients had only one bleeding episode per cycle. The incidence of amenorrhea ranged from 3.6% to 14.9%. Average cycle length and duration of bleeding were similar to the pretreatment values. High continuation rates (79% at 12 months) indicated good patient acceptance of the method. There were no contraceptive failures or serious side effects. Return of fertility was relatively prompt. Among 21 patients who had discontinued treatment in order to plan pregnancy, 10 were pregnant within six months, and 3 others conceived during the succeeding three months. In five volunteers, serum medroxyprogesterone acetate levels were below 5 ng/ml (with one exception) after a single injection of Cyclo-Provera given at intervals up to 56 days. 2018-06-01T06:27:18Z 2018-06-01T06:27:18Z 1978-01-01 Article International Journal of Gynecology and Obstetrics. Vol.16, No.1 (1978), 61-64 10.1002/j.1879-3479.1978.tb00396.x 00207292 2-s2.0-0018134466 https://repository.li.mahidol.ac.th/handle/123456789/13120 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0018134466&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
S. Koetsawang
S. Srisupandit
O. Kiriwat
A. Koetsawang
The monthly injectable contraceptive: A two year clinical trial
description A contraceptive regimen of monthly intramuscular injections of a combination of 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate (Cyclo-Provera, Upjohn Co, Kalamazoo, MI, USA) was studied in 111 Thai women through 2356 cycles. During the first two years of treatment, more than 80% of the patients had only one bleeding episode per cycle. The incidence of amenorrhea ranged from 3.6% to 14.9%. Average cycle length and duration of bleeding were similar to the pretreatment values. High continuation rates (79% at 12 months) indicated good patient acceptance of the method. There were no contraceptive failures or serious side effects. Return of fertility was relatively prompt. Among 21 patients who had discontinued treatment in order to plan pregnancy, 10 were pregnant within six months, and 3 others conceived during the succeeding three months. In five volunteers, serum medroxyprogesterone acetate levels were below 5 ng/ml (with one exception) after a single injection of Cyclo-Provera given at intervals up to 56 days.
author2 Mahidol University
author_facet Mahidol University
S. Koetsawang
S. Srisupandit
O. Kiriwat
A. Koetsawang
format Article
author S. Koetsawang
S. Srisupandit
O. Kiriwat
A. Koetsawang
author_sort S. Koetsawang
title The monthly injectable contraceptive: A two year clinical trial
title_short The monthly injectable contraceptive: A two year clinical trial
title_full The monthly injectable contraceptive: A two year clinical trial
title_fullStr The monthly injectable contraceptive: A two year clinical trial
title_full_unstemmed The monthly injectable contraceptive: A two year clinical trial
title_sort monthly injectable contraceptive: a two year clinical trial
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/13120
_version_ 1763497898778034176