Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin a via the adenosine receptor A<inf>1</inf>pathway

• Main Authors: Yuji Kan, Tamaki Okabayashi, Shin Ichi Yokota, Soh Yamamoto, Nobuhiro Fujii, Toshiharu Yamashita
• Other Authors: Sapporo Medical University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13389
• Institution: Mahidol University

Imiquimod is recognized as an agonist for Toll-like receptor 7 (TLR7) in immunocompetent cells. TLR7, as well as TLR3 and TLR8, triggers the immune responses, such as the production of type I interferons (IFNs) and proinflammatory cytokines via recognition of viral nucleic acids in the infected cell...