Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population
Background: The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. Methodology/Principal Findings: The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee c...
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th-mahidol.134442018-06-11T11:35:59Z Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population Wolfgang Stuetz Verena Ilona Carrara Rose McGready Sue Jean Lee Hans Konrad Biesalski François Henry Nosten Friedrich Schiller Universitat Jena Universitat Hohenheim Shoklo Malaria Research Unit Mahidol University Churchill Hospital Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Background: The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. Methodology/Principal Findings: The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee camp. Women were enrolled during antenatal care and followed after delivery. Samples were collected at 12 weeks post partum. Thiamine diphosphate (TDP) in whole blood and thiamine in breast-milk of 636 lactating women were measured. Thiamine in breast-milk consisted of thiamine monophosphate (TMP) in addition to thiamine, with a mean TMP to total thiamine ratio of 63%. Mean whole blood TDP (130 nmol/L) and total thiamine in breast-milk (755 nmol/L) were within the upper range reported for well-nourished women. The prevalence of women with low whole blood TDP ( < 65 nmol/L) was 5% and with deficient breast-milk total thiamine ( < 300 nmol/L) was 4%. Whole blood TDP predicted both breast-milk thiamine and TMP (R 2 = 0.36 and 0.10, p < 0.001). A ratio of TMP to total thiamine ≥63% was associated with a 7.5 and 4-fold higher risk of low whole blood TDP and deficient total breast-milk thiamine, respectively. Routine provision of daily 100 mg of thiamine mononitrate post-partum compared to the previous weekly 10 mg of thiamine hydrochloride resulted in significantly higher total thiamine in breast-milk. Conclusions/Significance: Thiamine supplementation for lactating women in Maela refugee camp is effective and should be continued. TMP and its ratio to total thiamine in breas t-milk, reported for the first time in this study, provided useful information on thiamine status and should be included in future studies of breast-milk thiamine. © 2012 Stuetz et al. 2018-06-11T04:30:26Z 2018-06-11T04:30:26Z 2012-06-29 Article PLoS ONE. Vol.7, No.6 (2012) 10.1371/journal.pone.0036280 19326203 2-s2.0-84863084916 https://repository.li.mahidol.ac.th/handle/123456789/13444 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863084916&origin=inward |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Wolfgang Stuetz Verena Ilona Carrara Rose McGready Sue Jean Lee Hans Konrad Biesalski François Henry Nosten Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
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Background: The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. Methodology/Principal Findings: The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee camp. Women were enrolled during antenatal care and followed after delivery. Samples were collected at 12 weeks post partum. Thiamine diphosphate (TDP) in whole blood and thiamine in breast-milk of 636 lactating women were measured. Thiamine in breast-milk consisted of thiamine monophosphate (TMP) in addition to thiamine, with a mean TMP to total thiamine ratio of 63%. Mean whole blood TDP (130 nmol/L) and total thiamine in breast-milk (755 nmol/L) were within the upper range reported for well-nourished women. The prevalence of women with low whole blood TDP ( < 65 nmol/L) was 5% and with deficient breast-milk total thiamine ( < 300 nmol/L) was 4%. Whole blood TDP predicted both breast-milk thiamine and TMP (R 2 = 0.36 and 0.10, p < 0.001). A ratio of TMP to total thiamine ≥63% was associated with a 7.5 and 4-fold higher risk of low whole blood TDP and deficient total breast-milk thiamine, respectively. Routine provision of daily 100 mg of thiamine mononitrate post-partum compared to the previous weekly 10 mg of thiamine hydrochloride resulted in significantly higher total thiamine in breast-milk. Conclusions/Significance: Thiamine supplementation for lactating women in Maela refugee camp is effective and should be continued. TMP and its ratio to total thiamine in breas t-milk, reported for the first time in this study, provided useful information on thiamine status and should be included in future studies of breast-milk thiamine. © 2012 Stuetz et al. |
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Friedrich Schiller Universitat Jena |
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Friedrich Schiller Universitat Jena Wolfgang Stuetz Verena Ilona Carrara Rose McGready Sue Jean Lee Hans Konrad Biesalski François Henry Nosten |
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Article |
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Wolfgang Stuetz Verena Ilona Carrara Rose McGready Sue Jean Lee Hans Konrad Biesalski François Henry Nosten |
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Wolfgang Stuetz |
title |
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
title_short |
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
title_full |
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
title_fullStr |
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
title_full_unstemmed |
Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
title_sort |
thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population |
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2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/13444 |
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1763488935814627328 |