Characterizations and proteome analysis of platelet-free plasma-derived microparticles in β-thalassemia/hemoglobin E patients

• Main Authors: Porntip Chaichompoo, Panida Kumya, Ladawan Khowawisetsut, Wararat Chiangjong, Sakdithep Chaiyarit, Nutkridta Pongsakul, Noppadol Sirithanaratanakul, Suthat Fucharoen, Visith Thongboonkerd, Kovit Pattanapanyasat
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13549

Aggregatability and oxidative damage of red blood cells (RBCs), platelet activation and increased amount of blood cells-derived microparticles (MPs) are thought to be the etiologies for the thrombotic risk in thalassemia, but with unclear mechanisms. Here we report cellular origins and increases in...