Establishment of a Shigella sonnei human challenge model in Thailand

• Main Authors: Ladaporn Bodhidatta, Punnee Pitisuttithum, Supat Chamnanchanant, Karen T. Chang, Dilara Islam, Valai Bussaratid, Malabi M. Venkatesan, Thomas L. Hale, Carl J. Mason
• Other Authors: Armed Forces Research Institute of Medical Sciences (AFRIMS)
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13573
• Institution: Mahidol University

In order to establish a human challenge model of Shigella related disease for vaccine testing, a dose-escalating inpatient trial was performed. Three groups of 12 healthy adult volunteers were orally challenged with 93,440 and 1680. CFU of Shigella sonnei strain 53G. Subjects were admitted to the Va...