CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients

• Main Authors: Ekaphop Sirachainan, Sureerat Jaruhathai, Narumol Trachu, Ravat Panvichian, Thitiya Sirisinha, Touch Ativitavas, Vorachai Ratanatharathorn, Montri Chamnanphon, Chonlaphat Sukasem
• Other Authors: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13591
• Institution: Mahidol University

Aim: We evaluated single nucleotide polymorphisms (SNPs) of CYP2D6 to identify those that influence the efficiency of tamoxifen in adjuvant treatment of breast cancer through a matched case-control study. Methods: Peripheral blood DNA was collected from 20 patients with disease recurrence during adj...