The morita-baylis-hillman reaction of chiral highly oxygenated cyclopent-2-enones

• Main Authors: Chonticha Masusai, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Chaveng Pakawatchai, Vichai Reutrakul, Manat Pohmakotr
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13601

The Morita-Baylis-Hillman (MBH) reactions of (4S,5R,7R,8R)- and (4R,5R,7R,8R)-4-hydroxy-7,8-dimethoxy-7,8-dimethyl-6,9-dioxaspiro[4.5] dec-2-en-1-ones (2 and 3, resp.) with aldehydes using various catalysts were studied. A combination of Bu 3 P/phenol in THF was found being optimum conditions givin...