Periostin activates integrin α5β1 through a PI3K/AKT-dependent, pathway in invasion of cholangiocarcinoma

• Main Authors: Kusumawadee Utispan, Jumaporn Sonongbua, Peti Thuwajit, Siri Chau-In, Chawalit Pairojkul, Sopit Wongkham, Chanitra Thuwajit
• Other Authors: Khon Kaen University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13624
• Institution: Mahidol University

Periostin (PN) is mainly produced from stromal fibroblasts in cholangiocarcinoma (CCA) and shows strong impact in cancer promotion. This work aimed to investigate the mechanism that PN uses to drive CCA invasion. It was found that ITGα5β1 and α6β4 showed high expression in non-tumorigenic biliary ep...