Implementation of proteomic biomarkers: Making it work

• Main Authors: Harald Mischak, John P.A. Ioannidis, Angel Argiles, Teresa K. Attwood, Erik Bongcam-Rudloff, Mark Broenstrup, Aristidis Charonis, George P. Chrousos, Christian Delles, Anna Dominiczak, Tomasz Dylag, Jochen Ehrich, Jesus Egido, Peter Findeisen, Joachim Jankowski, Robert W. Johnson, Bruce A. Julien, Tim Lankisch, Hing Y. Leung, David Maahs, Fulvio Magni, Michael P. Manns, Efthymios Manolis, Gert Mayer, Gerjan Navis, Jan Novak, Alberto Ortiz, Frederik Persson, Karlheinz Peter, Hans H. Riese, Peter Rossing, Naveed Sattar, Goce Spasovski, Visith Thongboonkerd, Raymond Vanholder, Joost P. Schanstra, Antonia Vlahou
• Other Authors: University of Glasgow
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13629
• Institution: Mahidol University

While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid...