Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice

• Main Authors: Joanne M. Lumsden, Saule Nurmukhambetova, Jennifer H. Klein, Jetsumon Sattabongkot, Jason W. Bennett, Sylvie Bertholet, Christopher B. Fox, Steven G. Reed, Christian F. Ockenhouse, Randall F. Howard, Mark E. Polhemus, Anjali Yadava
• Other Authors: Walter Reed Army Institute of Research
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13732
• Institution: Mahidol University

Plasmodium vivax is the major cause of malaria outside of sub-Saharan Africa and causes morbidity and results in significant economic impact in developing countries. In order to produce a P. vivax vaccine for global use, we have previously reported the development of VMP001, based on the circumsporo...