Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience
The aim of this study was to determine outcomes and prognostic features of children with acute lymphoblastic leukemia (ALL) treated with two modified St Jude Children's Research Hospital protocols at Ramathibodi Hospital (1997-2008). Event-free survival rates of the "previous protocol"...
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th-mahidol.137422018-06-11T12:11:56Z Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience Pacharapan Surapolchai Samart Pakakasama Nongnuch Sirachainan Usanarat Anurathapan Duantida Songdej Ampaiwan Chuansumrit Suradej Hongeng Mahidol University Faculty of Medicine, Thammasat University Biochemistry, Genetics and Molecular Biology Medicine The aim of this study was to determine outcomes and prognostic features of children with acute lymphoblastic leukemia (ALL) treated with two modified St Jude Children's Research Hospital protocols at Ramathibodi Hospital (1997-2008). Event-free survival rates of the "previous protocol" were 88.3 ± 3.3% and 83.0 ± 3.9% and of the "current protocol" were 89.9 ± 3.4% and 88.0 ± 3.8%, at 3 and 5 years, respectively. Adverse prognostic features were identified only in the previous protocol study, including obesity, presenting leukocytes > 100 × 10 9 /L, high-risk group, persistent blasts in a day-15 marrow and sepsis. Sepsis also conferred inferior overall survival rates of patients in both protocols. Steady improvement in cure rate over the past decade has clearly demonstrated the optimal use of treatment protocols and a multidisciplinary approach to implementing pediatric cancer care in Ramathibodi Hospital. Our future challenges are refinement in risk and treatment stratification and reduction of treatment-related toxicities, prioritizing death from infections. © 2012 Informa UK, Ltd. 2018-06-11T04:37:15Z 2018-06-11T04:37:15Z 2012-05-01 Article Leukemia and Lymphoma. Vol.53, No.5 (2012), 891-900 10.3109/10428194.2011.631156 10292403 10428194 2-s2.0-84859937762 https://repository.li.mahidol.ac.th/handle/123456789/13742 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859937762&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Pacharapan Surapolchai Samart Pakakasama Nongnuch Sirachainan Usanarat Anurathapan Duantida Songdej Ampaiwan Chuansumrit Suradej Hongeng Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
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The aim of this study was to determine outcomes and prognostic features of children with acute lymphoblastic leukemia (ALL) treated with two modified St Jude Children's Research Hospital protocols at Ramathibodi Hospital (1997-2008). Event-free survival rates of the "previous protocol" were 88.3 ± 3.3% and 83.0 ± 3.9% and of the "current protocol" were 89.9 ± 3.4% and 88.0 ± 3.8%, at 3 and 5 years, respectively. Adverse prognostic features were identified only in the previous protocol study, including obesity, presenting leukocytes > 100 × 10 9 /L, high-risk group, persistent blasts in a day-15 marrow and sepsis. Sepsis also conferred inferior overall survival rates of patients in both protocols. Steady improvement in cure rate over the past decade has clearly demonstrated the optimal use of treatment protocols and a multidisciplinary approach to implementing pediatric cancer care in Ramathibodi Hospital. Our future challenges are refinement in risk and treatment stratification and reduction of treatment-related toxicities, prioritizing death from infections. © 2012 Informa UK, Ltd. |
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Mahidol University |
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Mahidol University Pacharapan Surapolchai Samart Pakakasama Nongnuch Sirachainan Usanarat Anurathapan Duantida Songdej Ampaiwan Chuansumrit Suradej Hongeng |
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Pacharapan Surapolchai Samart Pakakasama Nongnuch Sirachainan Usanarat Anurathapan Duantida Songdej Ampaiwan Chuansumrit Suradej Hongeng |
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Pacharapan Surapolchai |
title |
Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
title_short |
Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
title_full |
Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
title_fullStr |
Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
title_full_unstemmed |
Comparative outcomes of Thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
title_sort |
comparative outcomes of thai children with acute lymphoblastic leukemia treated with two consecutive protocols: 11-year experience |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/13742 |
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1763488293167562752 |