Divergent effects of 17-β-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-α-induced neointima formation

• Main Authors: Rungrat Nintasen, Kirsten Riches, Romana S. Mughal, Parnpen Viriyavejakul, Urai Chaisri, Yaowapa Maneerat, Neil A. Turner, Karen E. Porter
• Other Authors: University of Leeds
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13753
• Institution: Mahidol University

Coronary heart disease (CHD) is a condition characterized by increased levels of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α). TNF-α can induce vascular endothelial cell (EC) and smooth muscle cell (SMC) dysfunction, central events in development of neointimal lesions. The re...