Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis
Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberc...
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th-mahidol.137592018-06-11T12:23:45Z Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis Sanya Sureram Sarath P D Senadeera Poonpilas Hongmanee Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Chulabhorn Research Institute Chulabhorn Graduate Institute Mahidol University South Carolina Commission on Higher Education Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved. 2018-06-11T04:37:44Z 2018-06-11T04:37:44Z 2012-04-15 Article Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905 10.1016/j.bmcl.2012.02.053 14643405 0960894X 2-s2.0-84859441948 https://repository.li.mahidol.ac.th/handle/123456789/13759 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859441948&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Sanya Sureram Sarath P D Senadeera Poonpilas Hongmanee Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
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Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved. |
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Chulabhorn Research Institute |
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Chulabhorn Research Institute Sanya Sureram Sarath P D Senadeera Poonpilas Hongmanee Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
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Article |
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Sanya Sureram Sarath P D Senadeera Poonpilas Hongmanee Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
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Sanya Sureram |
title |
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
title_short |
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
title_full |
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
title_fullStr |
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
title_full_unstemmed |
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis |
title_sort |
antimycobacterial activity of bisbenzylisoquinoline alkaloids from tiliacora triandra against multidrug-resistant isolates of mycobacterium tuberculosis |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/13759 |
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1763487180522520576 |