Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
Objectives: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality. Animals: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs whic...
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th-mahidol.137822018-06-11T12:27:17Z Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease Melanie J. Hezzell Adrian Boswood Walasinee Moonarmart Jonathan Elliott Royal Veterinary College University of London Mahidol University Biochemistry, Genetics and Molecular Biology Veterinary Objectives: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality. Animals: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs which died during the study period (n = 102) were included in statistical analyses. Methods: Prospective cohort study comparing the rate of change of echocardiographic variables between dogs that experienced cardiac mortality and those that experienced non-cardiac mortality. Measurements were repeated approximately every 6 months and repeated measures linear models were constructed to estimate the rate of change of each variable over time. Results: Left ventricular (LV) end-diastolic diameter, normalized for body weight (LVEDDN) increased over time in both mortality groups. LV end-systolic diameter, normalized for body weight (LVESDN), LV end-diastolic diameter to LV free wall thickness in diastole (LVEDD/LVFWd) ratio, E wave velocity, E- to A-wave velocity ratio and left atrial to aortic root diameter ratio all increased over time in the cardiac mortality group, but did not change in the non-cardiac mortality group. MR velocity decreased over time in the cardiac mortality group but did not change in the non-cardiac mortality group. Tricuspid regurgitation jet velocity increased over time in both mortality groups. A wave velocity and fractional shortening did not change over time in either mortality group. Conclusions: Serial echocardiographic examination every 6-12 months is useful to identify dogs with progressive MMVD that are at increased risk of cardiac mortality. © 2012 Elsevier B.V. All rights reserved. 2018-06-11T04:38:44Z 2018-06-11T04:38:44Z 2012-03-01 Article Journal of Veterinary Cardiology. Vol.14, No.1 (2012), 269-279 10.1016/j.jvc.2012.01.009 18750834 17602734 2-s2.0-84858449938 https://repository.li.mahidol.ac.th/handle/123456789/13782 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84858449938&origin=inward |
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Biochemistry, Genetics and Molecular Biology Veterinary Melanie J. Hezzell Adrian Boswood Walasinee Moonarmart Jonathan Elliott Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
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Objectives: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality. Animals: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs which died during the study period (n = 102) were included in statistical analyses. Methods: Prospective cohort study comparing the rate of change of echocardiographic variables between dogs that experienced cardiac mortality and those that experienced non-cardiac mortality. Measurements were repeated approximately every 6 months and repeated measures linear models were constructed to estimate the rate of change of each variable over time. Results: Left ventricular (LV) end-diastolic diameter, normalized for body weight (LVEDDN) increased over time in both mortality groups. LV end-systolic diameter, normalized for body weight (LVESDN), LV end-diastolic diameter to LV free wall thickness in diastole (LVEDD/LVFWd) ratio, E wave velocity, E- to A-wave velocity ratio and left atrial to aortic root diameter ratio all increased over time in the cardiac mortality group, but did not change in the non-cardiac mortality group. MR velocity decreased over time in the cardiac mortality group but did not change in the non-cardiac mortality group. Tricuspid regurgitation jet velocity increased over time in both mortality groups. A wave velocity and fractional shortening did not change over time in either mortality group. Conclusions: Serial echocardiographic examination every 6-12 months is useful to identify dogs with progressive MMVD that are at increased risk of cardiac mortality. © 2012 Elsevier B.V. All rights reserved. |
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Royal Veterinary College University of London |
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Royal Veterinary College University of London Melanie J. Hezzell Adrian Boswood Walasinee Moonarmart Jonathan Elliott |
format |
Article |
author |
Melanie J. Hezzell Adrian Boswood Walasinee Moonarmart Jonathan Elliott |
author_sort |
Melanie J. Hezzell |
title |
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
title_short |
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
title_full |
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
title_fullStr |
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
title_full_unstemmed |
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
title_sort |
selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/13782 |
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1763496630527459328 |