Single nucleotide polymorphisms in the toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine

• Main Authors: Catrin E. Moore, Branwen J. Hennig, Kirsten P. Perrett, J. Claire Hoe, Sue J. Lee, Helen Fletcher, Denise Brocklebank, Daniel O'Connor, Matthew D. Snape, Andrew J. Hall, Shelley Segal, Adrian V.S. Hill, Andrew J. Pollarda
• Other Authors: University of Oxford
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13795
• Institution: Mahidol University

The rate of decay of antibody concentration following serogroup C meningococcal (MenC) polysaccharide-protein conjugate vaccination varies between individuals. This depends partly on vaccination age but may be influenced by human genetics. We studied 721 single nucleotide polymorphisms (SNPs) across...