Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: Potential therapy for cholera and polycystic kidney disease

• Main Authors: Chatchai Muanprasat, Lalida Sirianant, Sunhapas Soodvilai, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Varanuj Chatsudthipong
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13802

Overstimulation of cAMP-activated Cl - secretion can cause secretory diarrhea. Isoliquiritigenin (ISLQ) is a plant-derived chalcone that has a wide range of biological activities. The present study thus aimed to investigate the effect of ISLQ on cAMP-activated Cl - secretion in human intestinal...