HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX ® B/E

• Main Authors: Robert Paris, Sasitorn Bejrachandra, Prasert Thongcharoen, Sorachai Nitayaphan, Punnee Pitisuttithum, Anna Sambor, Sanjay Gurunathan, Donald Francis, Silvia Ratto-Kim, Chitraporn Karnasuta, Mark S. de Souza, Victoria R. Polonis, Arthur E. Brown, Jerome H. Kim, Henry A. Stephens
• Other Authors: Armed Forces Research Institute of Medical Sciences, Thailand
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13823
• Institution: Mahidol University

Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 pr...